Laboratory

Variable Density Extruder & Multi Bowl Spheronizer Variable Density Kit

This bench-top system comprises of two machines, the Variable Density Extruder and the Multi Bowl Spheronizer, and offers flexibility over batch size from 150 g to 1 kg. 
  • Include pellets of variable density in your development programme
  • Multiple dies available with various hole diameters and depths for variable density extrudate and pellets
  • Increase your chances of development success by increasing your options.

 

Description

The Caleva Variable Density Kit allows you to develop pellets with different densities, increasing your chances of achieving a successful formulation with the best pellet characteristics for your needs. The kit is made up of the Caleva Variable Density Extruder and the bench-top Multi Bowl Spheronizer. 

The Caleva Variable Density Extruder is a bench-top extruder designed to give you the ability to produce experimental formulation applications with different densities. It is a novel screw extruder design with both axial and radial head configurations. The axial head configuration has different screen thicknesses available from 1 mm to 12 mm. The radial head configuration has various dies available with holes diameters ranging from 0.5mm to 8 mm, with different die depths available. Also available are dies with lobed profiles for increasing the surface area of extrudate which is ideal for some chemical applications. 

Extrudate Density: The density of the extrudate of any given diameter varies as a function of the extruder screen hole length thus the name of the Variable Density Extruder. So by changing a screen hole depth you can increase the density of the extrudate. This can offer several advantages depending on the end use of the product.

Extrudate Quality: The extrudate quality improves dramatically as the density increases, exhibiting smoother surfaces with less breaks and voids. If this extrudate is used for spheronization then this can lead to spheres that are very consistent in both their “roundness” and size distribution which can result in higher usable yields.

Caleva offer equipment for production as well as bench-top equipment for formulation development and proof-of-concept work.  All of our laboratory equipment is designed to facilitate fast, and trouble free, scale up to production.

Downloads

When you are developing pellets would it be useful to you if you could:
  • Modify the porosity of your pellets?
  • Modify your pellet dissolution profiles?
  • Make your pellets more uniform in size and shape?
  • Increase drug loading in your single dose unit?
  • Use the optimum extrusion density for your formulation?
You may use the Variable Density Kit to:
  • Expand the number of options you can investigate during your formulation development
  • Generate a greater chance for your formulation to be successful
  • Boost the active material content in your unit dose for clinical trial samples
  • Give your customers confidence in your development programme.

 

 

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