View-the-Multi-Lab-Classic

 

All-in-One

Caleva Multi Lab - Remarkable R&D Mix, Granulate, Extrude & Spheronize

Work with batch sizes from 10g up to 50g (formulation dependent)


"First, we love the multilab machine!!!  It is being used every day for multiple projects and we are getting outstanding results and some technology breakthroughs"
Graeme J. Millar  |  Professor |  Science & Engineering Faculty
Queensland University of Technology


 

Watch the Caleva Multi Lab Turn Powder into Pellets

 

Open each tab to learn more about the capabilities of the Caleva Multi Lab

  • Variable-Density

    Variable Density

    Discover what Variable Density Extrusion can do for you

     

  • hand-screws

    R&D Success

    Specialized attachments and design features to increase your chances of development success 

  • time-in-minutes-to-complete-one-trial-1

    FastTrack Formula

    Develop your product faster.  Prove your concept quickly

  • blue-granulation

    Mix/Granulate

    A critical process in the creation of a successful formulation

  • catalyst-extrudate

    Catalysts

    Increase the surface area to volume ratio of your extrudate

  • caleva-multi-lab-small-footprint

    Very Small Footprint

    3 separate processes on a small, single base unit.

  • Variable-Density

    Variable Density

    Discover what Variable Density Extrusion can do for you

     

  •  

    Modify your extrudate density, hardness, friability, and porosity at a trial level

    If having complete control over the properties of your extrudate is important to you, then the variable density capabilities of the Multi Lab could be a crucial step in the right direction.
    The CMLs extrusion attachment comes with one standard die and one high density die at no extra cost. These dies give you the opportunity to explore more parameters in your formulation development process, increasing your chances of a successful outcome.
    (More die variants are available, contact us to learn more about the options available.)
    Density gain - reduced
    The graph above was created as a result of some experiments that we conducted with the CML and its variable density capabilities.
    Different extrusion density can change the properties of your formulation, increasing your chances of development success. The CML will enable you to be 100% sure that all available alternatives have been fully investigated at a small, low cost, fast and effective stage.
    If your initial trials with variable density extrusion show promising results you have the option to obtain additional dies from Caleva that provide a higher or lower than “standard” density output.
     

    Do you know what could happen to your extrudate if you modify it's density?

    You could:

    • Modify extrudate hardness and strength
    • Modify the porosity of your pellets
    • Modify your pellet dissolution profiles
    • Make your pellets more uniform
    Increase drug loading in a single dose unit
    • Look at the effect on product cohesion and the effect on physical stability
    • Look at the effect on chemical stability
     
    If any of these benefits are of interest to you. Contact us.
  • hand-screws

    R&D Success

    Specialized attachments and design features to increase your chances of development success 

  • time-in-minutes-to-complete-one-trial-1

    FastTrack Formula

    Develop your product faster.  Prove your concept quickly

  • blue-granulation

    Mix/Granulate

    A critical process in the creation of a successful formulation

  • catalyst-extrudate

    Catalysts

    Increase the surface area to volume ratio of your extrudate

  • caleva-multi-lab-small-footprint

    Very Small Footprint

    3 separate processes on a small, single base unit.

 

Frequently asked Questions about Mixing, Extruding & Spheronizing

 

 

 

Download our Introduction to Spheronization

Non-technical-guide-to-spheronization

Guide to Spheronization

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