Knowledge Base

Investigating drug dissolution enhancement and controlled release of solid-liquid hybrid dosage form using Liqui-Pellet technology.

Discover how the Caleva Multi Lab was used to demonstrate the flexibility and potential of Liqui-Pellets as the next generation oral dosage form.

Discover how Caleva extrusion and spheronization equipment supported a university master’s student in his scientific breakthrough, resulting in his publication in a recognised industry journal.

 Shaped Catalyst Body Preparation. Zeolite HZSM-5 (ACS Materials, M38) was mixed as a dry powder with alumina (Sasol, Catapal D (Boehmite)) and the required amount of Milli-Q water to ensure an optimum solid-to-liquid ratio for extrusion (measured using a Mixer Torque Rheometer, Caleva). The paste, containing a ratio of 70:30 wt % zeolite:binder, was extruded using a Mini-Screw Extruder (Caleva),...

Thanks to Caleva not only for making great equipment but also for being helpful to give us access to it within our budget. I would ALSO like to thank Caleva for the help given in providing the small scale extrusion and spheronization equipment for our laboratory. The latest research paper from our pharmaceutical department (Lipids bearing extruded-spheronized pellets for extended release of...

Tablets were coated with a color overcoat (Aquarius Cool Vanilla BI-1800,Ashland/Aqualon; hydroxypropylmethylcellulose, titanium dioxide, triacetin, polysorbate)using a Caleva air-suspension coater to 2-4% by weight …

Components were mixed with a specialist Caleva mixer to form a homogeneous paste

… Then the wet mass was extruded immediately with a radial extruder (Model 20 Extruder, Caleva Ltd, UK) that was fitted with a screen of 150 mm in diameter and 1.0 mm die holes. The extruder screen rotated at 30 rpm. After …

The different states of agglomeration were identified by the evolution of rheological properties under water addition and shearing conditions using a Caleva^®mixer torque rheometer.

Abstract: Spheronization is a rapid process for production of microspheres. The process involves the dry mixing of drug with microcrystalline cellulose (MCC), which on subsequent wetting with water forms a plastic mass suitable for extrusion and spheronization. As in any pharmaceutical operation, large number of factors may affect the production of pellets, which can be related to formulation or...

Thanks to Caleva not only for making great equipment but also for being helpful to give us access to it within our budget. I would ALSO like to thank Caleva for the help given in providing the small scale extrusion and spheronization equipment for our laboratory. The latest research paper from our pharmaceutical department (Lipids bearing extruded-spheronized pellets for extended release of...